B1 One size doesn’t fit all: Dose individualisation with population pharmacology

Tuesday 12 September 2017
COEX Convention & Exhibition Center : Grand Ballroom 105 3 hours

Organised by the FIP Programme Committee and the FIP Special Interest Group on PK/PD & Systems Pharmacology

Chairs: Don Mager (University at Buffalo, USA) and Michael Ward (University of South Australia, Australia)


Most medicines have been developed for an “average” patient, with little to no concern for medicine responses in specific patient subpopulations or individuals. This “one-size-fits-all” approach often results in good performance in some patients but less than successful treatment outcomes in many others, including poor efficacy and/or adverse medicine reactions. This session directly addresses the critical unmet medical need of individualised pharmacotherapy. Population pharmacology enables personalised medicine therapy through the effective integration of individual patient characteristics, pharmacokinetic and pharmacodynamic principles, and computational algorithms capable of handling big data and mathematical models of medicine action.

Learning objectives

At the end of this knowledge -based session, the participants will be able to:

  1. Describe basic population-based pharmacokinetic-pharmacodynamic principles that underlie dosing regimen individualisation in specific diseases and special populations.
  2. Describe approaches for integrating pharmacogenomic data in population-based analyses for identifying sources of variability in medicine action.

Specify the utility of population pharmacology and feedback measurements obtained from patients for individualising warfarin and antibiotic dose individualisation.


09:00 – 09:40
1. Basic principles of applied pharmacometrics
Speaker TBA

09:40 – 10:20
2. Development of a model-based dose-individualisation approach with an application to routine clinical data
Jinju Guk (Yonsei University College of Medicine, Republic of Korea)

10:20 – 10:40 Coffee/tea break

10:40 – 11:20
3. Dose-individualisation of anticoagulants
Don Mager (University at Buffalo, USA)

11:20 -12:00
4. Optimising antimicrobial dosing regimens in clinical practice
Markus Zeitlinger (Medical University of Vienna, Austria)